DNA Gut analyzes and reports human genetic variants, based on scientific and clinically relevant evidence, which may predispose certain individuals to alterations in gut homeostasis. These alterations are known for their negative effects on health.
The report provides personalized interventions regarding diet, lifestyle, and nutraceuticals, to support relevant biological pathways and help achieve and maintain a healthy and resilient gastrointestinal tract.
The test is suitable for individuals who suffer from or are predisposed to:
- irritable bowel syndrome (IBS)
- inflammatory bowel disease (IBD)
- celiac disease
- gut dysbiosis
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non-celiac gluten sensitivity or lactose intolerance
- food sensitivities
- chronic bloating
- diarrhea or constipation
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autoimmune tendencies and recurrent infections
The test is also relevant for mental health conditions associated with gut health, including issues related to mood, cognition, and neurodegenerative diseases. It is also recommended for individuals seeking a preventive approach, focused on identifying the root causes of health problems.
DNA Gut report structure
The report organizes the results into a concise summary of priority biological pathways that influence the five pillars of gut health:
- Gut motility
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Presence of pathobionts (microorganisms that can become harmful under certain conditions)
- Abnormal microbial metabolite production
- Intestinal barrier integrity
- Immune system function
The results provide a lifelong “genetic fingerprint” of predispositions for gut health, presented through color-coded zones, which indicate potential risks.
Clear explanations and visual elements for each genetic variant and biological pathway, along with specific recommendations regarding diet, supplements, probiotics, and lifestyle, as well as suggestions for further tests (e.g., GI-MAP, Zonulin, Gluten Peptide, Stool OMX, SIBO, toxin panels, etc.), enable specialists to prioritize important areas and implement coordinated, targeted, and effective treatment strategies.
Link between gut microbiota and genes
There is extensive evidence showing how the gut microbiota influences our genes. Gut bacteria produce a wide range of compounds (microbial metabolites) that act as biological messengers. These metabolites can directly or indirectly influence gene expression, including by altering DNA methylation.
Gut microbes also influence the expression of genes involved in:
- immune response
- lipid metabolism
- glucose regulation
- nutrient absorption
On the other hand, the human genome also plays a major role in gut health by:
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Shaping the gut environment
- immune system genes that regulate which bacteria can colonize the gut
- proteins that form the intestinal lining and protective mucus layer
- digestive enzymes that break down food
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Influencing nutrient availability
- how the body processes and absorbs nutrients
- what substrates and cofactors are available for intestinal enzymes and gut microbiota
Knowledge of genetic risk variants, along with functional tests, allows for a better understanding of the patient's symptoms and provides deep insights into the factors contributing to disease development.
